6:09 PM: Per Ian Rapoport of NFL Network, Burrow has been diagnosed with turf toe. What this means for his availability to play will depend on the severity of the injury. Minor sprains can be overcome in just a few days’ time, while more serious sprains can require multiple weeks of recovery and even worse iterations can require surgery and a recovery timeline measured by months.
Rapoport cites Jeremy Rauch of FOX19 who in turn cites a source that claimed the injury is believed to involve torn ligaments, which could mean an absence of “several weeks” for Cincinnati’s QB1. The Bengals are the only NFL team with an MRI machine in their stadium, so they should have a good idea of his outlook, but they haven’t revealed much to the media at this point in time.
3:09 PM: The Bengals’ efforts to improve to 2-0 have hit a notable roadblock. Quarterback Joe Burrow suffered a toe injury midway through the second quarter of today’s game against the Jaguars. 
The injury occurred while Burrow was attempting to avoid pressure. The play resulted in a sack, and after receiving medical attention he walked off the field. Burrow was initially listed as questionable to return, but he has since officially been ruled out.
Burrow underwent an MRI shortly after suffering the injury. Once it was completed, the 28-year-old was seen using a scooter to return to the locker room with his left leg elevated (h/t FOX19’s Joe Danneman). Needless to say, further testing and updates will be critical in this situation over the coming days.
Throughout his decorated career, injuries have been a concern for Burrow. The former No. 1 pick suffered an ACL tear during his rookie season; he has also missed time due to a calf strain and a ruptured ligament in his wrist last season. During the Bengals’ Super Bowl loss, Burrow suffered an MCL sprain. If this latest ailment leads to more missed games, Cincinnati’s offense will be notably shorthanded.
The Bengals made an effort to buck the trend of slow starts early in regular seasons by playing Burrow and other key players during the preseason. That did not result in a productive outing in Week 1, although Cincinnati emerged with a one-point victory over Cleveland. Prior to going down today, Burrow completed seven of 13 pass attempts for 76 yards and one touchdown.
Backup Jake Browning has taken over under center. The 29-year-old made nine appearances and seven starts last season, completing a league-best 70.4% of his pass attempts. Browning has been in the organization since 2021, and he inked a two-year deal last spring. As a pending free agent, his performances will be key in determining his value on the open market (if he reaches it). Depending on Burrow’s outlook, Browning may be needed beyond the closing stages of today’s game.